Article

<i>Flamenco</i> plasticity tunes somatic piRNAs, rewiring host isoforms and opening a route to heritable transposon spread

2025-10-14

Abstract excerpt

Transposons drive genome innovation, yet how they evade somatic piRNA defenses, reach the germline, and rewire host genes with limited cost remains unclear. Using comparative long-read sequencing in Drosophila ovarian somatic cells (OSCs), we show that the LTR transposon Springer rewires gene expression by inserting into promoter-proximal introns at an AT-rich motif. Its 5′ LTR initiates transcripts that splice...

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Literature Corpus work: 8840f1d1-822f-5fb3-b831-8ef7768fe0d5
DOI: 10.1101/2025.10.13.681963

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