Article

Genomic copy-number loss is rescued by self-limiting production of DNA circles

2018-01-29

Abstract excerpt

<h4>Summary</h4> Copy-number changes generate phenotypic variability in health and disease. Whether organisms protect against copy-number changes is largely unknown. Here, we show that Saccharomyces cerevisiae monitors the copy number of its ribosomal DNA (rDNA) and rapidly responds to copy-number loss with the clonal amplification of extrachromosomal rDNA circles (ERCs) from chromosomal repeats. ERC production...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ccc27d96-0d38-5e59-a5df-623d4a55eef6
DOI: 10.1101/255471

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic copy-number loss is rescued by self-limiting production of DNA circlesDOI 10.1101/255471Read

Synthetic expansion of non-coding DNA reveals physiological constraints on genome sizeSemantic proximity Read

Hotspot of <i>de novo</i> telomere addition stabilizes linear amplicons in yeast grown in sulfate-limiting conditionsSemantic proximity Read

Transgenerational dynamics of rDNA copy number in <i>Drosophila</i> male germline stem cellsSemantic proximity Read

Replicative aging is associated with loss of genetic heterogeneity from extrachromosomal circular DNA in Saccharomyces cerevisiae.Semantic proximity Read

Single-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination.Semantic proximity Read

Insulin signaling regulates R2 retrotransposon expression to orchestrate transgenerational rDNA copy number maintenanceSemantic proximity Read

Ribosomal DNA copy number loss and sequence variation in cancer.Semantic proximity Read

Replicating and cycling stores of information perpetuate lifeSemantic proximity Read

Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells.Semantic proximity Read

Genome-wide copy number analysis of single cellsSemantic proximity Read

Dosage compensation can buffer copy-number variation in wild yeast.Semantic proximity Read

Contribution of Spontaneous Mutations to Quantitative and Molecular Variation at the Highly Repetitive rDNA Locus in Yeast.Semantic proximity Read