Article

Checkpoint-dependent sensitivities to nucleoside analogues uncover specific patterns of genomic instability

2025-07-14

Abstract excerpt

<h4>ABSTRACT</h4> Nucleoside analogues are used as drugs and as labels in lab-based research. However, the effect of different nucleoside analogue mechanism(s) on cell sensitivity or mutagenesis is unclear. This is particularly important in cancer treatments where checkpoint proteins and DNA damage factors are often mutated. We tested 6 nucleoside analogues in the fission yeast, Schizosaccharomyces pombe . We fo...

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Literature Corpus work: e2eb6000-953d-50b0-a44e-f3279e62d946
DOI: 10.1101/2025.07.13.664472

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