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Article

A mammalian-like DNA damage response of fission yeast to nucleoside analogs.

Genetics - 1 Jan 2013

Sabatinos Sarah A, Mastro Tara L, Green Marc D, Forsburg Susan L

Abstract excerpt

Nucleoside analogs are frequently used to label newly synthesized DNA. These analogs are toxic in many cells, with the exception of the budding yeast. We show that Schizosaccharomyces pombe behaves similarly to metazoans in response to analogs 5-bromo-2'-deoxyuridine (BrdU) and 5-ethynyl-2'-deoxyuridine (EdU). Incorporation causes DNA damage that activates the damage checkpoint kinase Chk1 and sensitizes cells to...

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Identifiers

PMID: 23150603
DOI: 10.1534/genetics.112.145730
PMCID: PMC3527242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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