Article

DNMT3A harboring leukemia-associated mutations directs sensitivity to DNA damage at replication forks

2021-05-28

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the DNA methyltransferase 3A ( DNMT3A ) gene are recurrent in de novo acute myeloid leukemia (AML) and are associated with resistance to standard chemotherapy, disease relapse, and poor prognosis, especially in advanced-age patients. Previous gene expression studies in cells with DNMT3A mutations identified deregulation of cell cycle-related signatures implicated in DNA damage re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d37592f2-cd0e-5f18-8c13-b02f392f1c89
DOI: 10.1101/2021.05.28.445639

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNMT3A harboring leukemia-associated mutations directs sensitivity to DNA damage at replication forksDOI 10.1101/2021.05.28.445639Read

DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks.Semantic proximity Read

Combination strategies to promote sensitivity to cytarabine-induced replication stress in acute myeloid leukemia with and without DNMT3A mutations.Semantic proximity Read

GSK-3484862 targets DNMT1 for degradation in cellsSemantic proximity Read

DNA methyltransferase 1 knockdown activates a replication stress checkpoint.Semantic proximity Read

Analysis of Genomic DNA Methylation and Gene Transcription Modulation Induced by DNMT3A Deficiency in HEK293 CellsSemantic proximity Read

Delayed Trp53 activation protects Dnmt3a-mutant hematopoietic stem cells from inflammatory attrition.Semantic proximity Read

Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication CheckpointSemantic proximity Read

The methyltransferase domain of DNMT1 is an essential domain in acute myeloid leukemia independent of DNMT3A mutation.Semantic proximity Read

Analysis of genomic DNA methylation and gene transcription modulation induced by <i>DNMT3A</i> deficiency in HEK293 cellsSemantic proximity Read

Hotspot DNMT3A mutations in Clonal Hematopoiesis and Acute Myeloid Leukemia sensitize cells to Azacytidine via viral mimicry responseSemantic proximity Read

Remethylation of Dnmt3a-/- hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing.Semantic proximity Read

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In VivoSemantic proximity Read