Article
Yeast mutants as a model system for identification of determinants of chemosensitivity.
Pharmacological reviews - 1 Dec 2000
Perego P, Jimenez G S, Gatti L, Howell S B, Zunino F
Abstract excerpt
The fission yeast Schizosaccharomyces pombe and the budding yeast Saccharomyces cerevisiae have become valuable tools for the study of basic cellular functions of eukaryotic cells, including DNA repair mechanisms and cell cycle control. Since the major signaling pathways and cellular processes involved in cellular response to cytotoxic agents are conserved between yeasts and mammalian cells, these simple...
Topics
- Animals
- Antineoplastic Agents
- DNA Damage
- DNA Repair
- Humans
- Mutation
- Recombination, Genetic
- Yeasts