Article
Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
DNA repair - 1 May 2009
Deshpande Gaurang P, Hayles Jacqueline, Hoe Kwang-Lae, Kim Dong-Uk, Park Han-Oh, Hartsuiker Edgar
Abstract excerpt
The maintenance of genome stability is essential for an organism to avoid cell death and cancer. Based on screens for mutant sensitivity against DNA damaging agents a large number of DNA repair and DNA damage checkpoint genes have previously been identified in genetically amenable model organisms. These screens have however not been exhaustive and various genes have been, and remain to be, identified by other...
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