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Article

A method for assaying the sensitivity of Drosophila replication checkpoint mutants to anti-cancer and DNA-damaging drugs.

Genome - 1 Oct 2002

Radcliffe Colleen M, Silva Elizabeth A, Campbell Shelagh D

Abstract excerpt

In multi-cellular organisms, failure to properly regulate cell-cycle progression can result in inappropriate cell death or uncontrolled cell division leading to tumor formation. To guard against such events, conserved regulatory mechanisms called "checkpoints" block progression into mitosis in response to DNA damage and incomplete replication, as well as in response to other signals. Checkpoint mutants in...

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PMID: 12416620
DOI: 10.1139/g02-051

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