Article

Maintaining transcriptome solubility constrains mRNA sequence composition

2025-09-20

Abstract excerpt

RNA is built from a four-nucleotide alphabet. Complementary sequences inevitably arise, creating pervasive opportunities for promiscuous RNA–RNA interactions. Here, we show that this chemistry makes the transcriptome intrinsically prone to self-association. We simulated the simultaneous interactions of ~7,500 mRNAs representing the E. coli transcriptome at physiological concentrations. These large-scale simulatio...

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Literature Corpus work: e2e863f6-2501-506c-bb23-cf2f8c4b7664
DOI: 10.1101/2025.09.19.677370

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