Article

RBPamp: Quantitative Modeling of Protein-RNA Interactions <i>in vitro</i> Predicts <i>in vivo</i> Binding

2022-11-09

Abstract excerpt

RNA-binding proteins (RBPs) control the processing and function of cellular transcripts to effect post-transcriptional gene regulation. Sequence-specific binding of RBPs to millions of synthetic RNAs has been probed in vitro by RNA Bind-n-Seq (RBNS). Here we describe RBPamp, a bio-physically-based model of protein-RNA interactions and associated algorithm that inferred affinity spectra of 79 diverse human RBPs fro...

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Literature Corpus work: a000d47d-4aef-5d45-ada6-3f8e4473fe94
DOI: 10.1101/2022.11.08.515616

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