Article

rG4-seeker enables high-confidence identification of novel and non-canonical rG4 motifs from rG4-seq experiments

2020-02-02

Abstract excerpt

<h4>ABSTRACT</h4> We recently developed the rG4-seq method to detect and map in vitro RNA G-quadruplex (rG4s) structures on a transcriptome-wide scale. rG4-seq of purified human HeLa RNA has revealed many non-canonical rG4s and the effects adjacent sequences have on rG4 formation. In this study, we aimed to improve the outcomes and false-positive discrimination in rG4-seq experiments using a bioinformatic approa...

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Literature Corpus work: 1b77fec0-436d-5356-a232-73042605c058
DOI: 10.1101/2020.02.01.929851

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