Article
Molecular crowders and cosolutes promote folding cooperativity of RNA under physiological ionic conditions.
RNA (New York, N.Y.) - 1 Mar 2014
Strulson Christopher A, Boyer Joshua A, Whitman Elisabeth E, Bevilacqua Philip C
Abstract excerpt
Folding mechanisms of functional RNAs under idealized in vitro conditions of dilute solution and high ionic strength have been well studied. Comparatively little is known, however, about mechanisms for folding of RNA in vivo where Mg(2+) ion concentrations are low, K(+) concentrations are modest, and concentrations of macromolecular crowders and low-molecular-weight cosolutes are high. Herein, we apply a...
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