Article

A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxB

2023-05-30

Abstract excerpt

Myxovirus resistance proteins (MxA and MxB) are interferon-induced proteins that exert antiviral activity against a diverse range of RNA and DNA viruses. In primates, MxA has been shown to inhibit myxoviruses, bunyaviruses, and hepatitis B virus, whereas MxB restricts retroviruses and herpesviruses. As a result of their conflicts with viruses, both genes have been undergoing diversifying selection during primate e...

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Literature Corpus work: e2776742-44a0-54fa-a8e9-5f4519095249
DOI: 10.1101/2023.05.30.542951

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