Article

Deciphering lentiviral Vpr/Vpx determinants required for HUSH and SAMHD1 antagonism highlights the molecular plasticity of these evolutionary conflicts

2024-03-07

Abstract excerpt

<h4>ABSTRACT</h4> SAMHD1 and the HUSH complex constitute two blocks during primate lentivirus infection, the first by limiting reverse transcription and the second by inhibiting proviral expression. Vpr and Vpx of specific lentiviral lineages have evolved to antagonize these antiviral proteins. While the antagonism of SAMHD1 has been well characterized, the evolutionary and molecular determinants of the antagonis...

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Literature Corpus work: 15808aaa-3f22-5490-8974-81b7d77de3e8
DOI: 10.1101/2024.03.07.583867

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