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Article

A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages

11 Oct 2018

Abstract excerpt

As antimicrobial signalling molecules, type III or lambda interferons (IFNλs) are critical for defence against infection by diverse pathogens, including bacteria, fungi and viruses. Counter-intuitively, expression of one member of the family, IFNλ4, is associated with decreased clearance of hepatitis C virus (HCV) in the human population; by contrast, a natural frameshift mutation that abrogates IFNλ4 production...

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PMID: 30308076
DOI: 10.1371/journal.ppat.1007307

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