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Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction

10 Dec 2015

Abstract excerpt

Viruses impose diverse and dynamic challenges on host defenses. Diversifying selection of codons and gene copy number variation are two hallmarks of genetic innovation in antiviral genes engaged in host-virus genetic conflicts. The myxovirus resistance (Mx) genes encode interferon-inducible GTPases that constitute a major arm of the cell-autonomous defense against viral infection. Unlike the broad antiviral...

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PMID: 26658285
DOI: 10.1371/journal.ppat.1005304

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