Evolutionary analysis identifies an MX2 haplotype associated with natural resistance to HIV-1 infection.

doi:10.1093/molbev/msu193

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Evolutionary analysis identifies an MX2 haplotype associated with natural resistance to HIV-1 infection.

Molecular biology and evolution - 1 Sept 2014

Sironi Manuela, Biasin Mara, Cagliani Rachele, Gnudi Federica, Saulle Irma, Ibba Salomè, Filippi Giulia, Yahyaei Sarah, Tresoldi Claudia, Riva Stefania, Trabattoni Daria, De Gioia Luca, Lo Caputo Sergio, Mazzotta Francesco, Forni Diego, Pontremoli Chiara, Pineda Juan Antonio, Pozzoli Uberto, Rivero-Juarez Antonio, Caruz Antonio, Clerici Mario

Abstract excerpt

The protein product of the myxovirus resistance 2 (MX2) gene restricts HIV-1 and simian retroviruses. We demonstrate that MX2 evolved adaptively in mammals with distinct sites representing selection targets in distinct branches; selection mainly involved residues in loop 4, previously shown to carry antiviral determinants. Modeling data indicated that positively selected sites form a continuous surface on loop 4,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disease Resistance

Share to Evolution, Molecular

Share to HIV-1

Share to HIV Infections

Share to Myxovirus Resistance Proteins

Share to Selection, Genetic

Share to White People

Source

Open in PubMed

Identifiers

PMID: 24930137
DOI: 10.1093/molbev/msu193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary analysis identifies an MX2 haplotype associated with natural resistance to HIV-1 infection.PMID 24930137Read ↗

Host and Viral Determinants of Mx2 Antiretroviral ActivitySemantic proximity Read ↗

Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus RestrictionSemantic proximity Read ↗

A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxBSemantic proximity Read ↗

The highly polymorphic cyclophilin A-binding loop in HIV-1 capsid modulates viral resistance to MxBSemantic proximity Read ↗

Accumulation of MxB/Mx2-resistant HIV-1 Capsid Variants During Expansion of the HIV-1 Epidemic in Human Populations.Semantic proximity Read ↗

The evolutionary history of the CCR5-Delta32 HIV-resistance mutation.Semantic proximity Read ↗

Weaker HLA Footprints on HIV in the Unique and Highly Genetically Admixed Host Population of Mexico.Semantic proximity Read ↗

Heterozygous and generalist MxA super-restrictors overcome breadth-specificity tradeoffs in antiviral restrictionSemantic proximity Read ↗

Human population structure and the adaptive response to pathogen-induced selection pressuresSemantic proximity Read ↗

Host genetics and immune control of HIV-1 infection: fine mapping for the extended human MHC region in an African cohort.Semantic proximity Read ↗

An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and PathogenesisSemantic proximity Read ↗

Structural modeling and experimental validation define the MxA-Thogotovirus nucleoprotein interface that drives restriction and escapeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.