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Article

High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans.

Current biology : CB - 10 Jan 2006

Sawyer Sara L, Wu Lily I, Akey Joshua M, Emerman Michael, Malik Harmit S

Abstract excerpt

The intracellular TRIM5alpha protein successfully inhibits HIV-1 infection in rhesus monkeys, but not in humans . A few amino acids in the virus-interacting SPRY domain were found to be responsible for most of this anti-viral specificity , raising the possibility that genetic variation among huma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16401428
DOI: 10.1016/j.cub.2005.11.045

Genes

TRIM5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16401428-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans.PMID 16401428Read ↗

Positive selection of primate <i>TRIM5</i> α identifies a critical species-specific retroviral restriction domainSemantic proximity Read ↗

Role of common human TRIM5alpha variants in HIV-1 disease progression.Semantic proximity Read ↗

Wild type and H43Y variant of human TRIM5alpha show similar anti-human immunodeficiency virus type 1 activity both in vivo and in vitro.Semantic proximity Read ↗

The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates.Semantic proximity Read ↗

TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys.Semantic proximity Read ↗

Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races.Semantic proximity Read ↗

Restriction of an Extinct Retrovirus by the Human TRIM5α Antiviral ProteinSemantic proximity Read ↗

Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities.Semantic proximity Read ↗

A TRIM5alpha exon 2 polymorphism is associated with protection from HIV-1 infection in the Pumwani sex worker cohort.Semantic proximity Read ↗

TRIM5 alpha drives SIVsmm evolution in rhesus macaques.Semantic proximity Read ↗

Ancient and recent adaptive evolution in the antiviral TRIM22 gene: identification of a single-nucleotide polymorphism that impacts TRIM22 function.Semantic proximity Read ↗

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