Article

Gorilla APOBEC3 restricts SIVcpz and influences lentiviral evolution in great ape cross-species transmissions

2018-07-04

Abstract excerpt

<h4>Summary</h4> Restriction factors including APOBEC3 family proteins have the potential prevent cross-species lentivirus transmissions. Such events as well as ensuing pathogenesis require the viral Vif protein to overcome/neutralize/degrade the APOBEC3 enzymes of the new host species. Previous investigations have focused on the molecular interaction between human APOBEC3s and HIV-1 Vif. However, the evolutionar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b29c6ada-9c4c-5bd2-ab4d-c798d3768cac
DOI: 10.1101/362079

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gorilla APOBEC3 restricts SIVcpz and influences lentiviral evolution in great ape cross-species transmissionsDOI 10.1101/362079Read

A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humansSemantic proximity Read

HIV-1 Vif Gained Breadth in APOBEC3G Specificity after Cross-Species Transmission of Its Precursors.Semantic proximity Read

Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate LentivirusesSemantic proximity Read

HIV-1 Vif gained breadth in APOBEC3G specificity after cross-species transmission of its precursorsSemantic proximity Read

Stably expressed APOBEC3H forms a barrier for cross-species transmission of simian immunodeficiency virus of chimpanzee to humansSemantic proximity Read

The Battle between Retroviruses and APOBEC3 Genes: Its Past and Present.Semantic proximity Read

The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict.Semantic proximity Read

APOBEC3G Splicing Defects in Nonhuman Primate Models Result in Disparate Viral Mutational Profiles Relative to HumansSemantic proximity Read

The Role of the Antiviral APOBEC3 Gene Family in Protecting Chimpanzees against Lentiviruses from MonkeysSemantic proximity Read

Convergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of simian immunodeficiency viruses.Semantic proximity Read

APOBEC3G Polymorphism as a Selective Barrier to Cross-Species Transmission and Emergence of Pathogenic SIV and AIDS in a Primate HostSemantic proximity Read

Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G AntagonismSemantic proximity Read