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Article

Accumulation of MxB/Mx2-resistant HIV-1 Capsid Variants During Expansion of the HIV-1 Epidemic in Human Populations.

EBioMedicine - 1 Jun 2016

Wei Wei, Guo Haoran, Ma Min, Markham Richard, Yu Xiao-Fang

Abstract excerpt

Recent studies have identified human myxovirus resistance protein 2 (MxB or Mx2) as an interferon induced inhibitor of HIV-1 replication. However, whether HIV-1 can overcome MxB restriction without compromise of viral fitness has been undefined. Here, we have discovered that naturally occurring capsid (CA) variants can render HIV-1 resistant to the activity of MxB without losing viral infectivity or the ability...

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Identifiers

PMID: 27428433
DOI: 10.1016/j.ebiom.2016.04.020
PMCID: PMC4919602

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