Article

Utility of Polygenic Risk Scores in Families with Exceptional Longevity

2025-07-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Polygenic risk scores (PRS) have been used to assess an individual’s risk for various diseases, including Alzheimer’s disease (AD). This study applied the PRS approach to a cohort of families ascertained for healthy aging, that have shown a reduced risk of AD. Using the SNPs identified as significantly associated with AD in the study by Kunkle and colleagues, we examined t...

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Literature Corpus work: e25a58fb-5574-53d4-be3a-7afc2aa970cf
DOI: 10.1101/2025.07.21.25331660

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