Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores.

Abstract excerpt

Polygenic Risk Scores (PRS) for AD offer unique possibilities for reliable identification of individuals at high and low risk of AD. However, there is little agreement in the field as to what approach should be used for genetic risk score calculations, how to model the effect of APOE, what the optimal p-value threshold (pT) for SNP selection is and how to compare scores between studies and methods. We show that...

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• Alzheimer Disease
• Apolipoproteins E
• Genetics, Population
• Genome-Wide Association Study
• Multifactorial Inheritance