Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pitfalls of predicting age-related traits by polygenic risk scores.

Annals of human genetics - 1 Sept 2023

Escott-Price Valentina, Schmidt Karl Michael

Abstract excerpt

Polygenic risk scores (PRS) are a method increasingly used to capture the combined effect of genome-wide significant variants and those which individually do not show genome-wide significant association but are likely to contribute to the risk of developing diseases. However, their practical use incurs complications and inconsistencies that so far limit their clinical applicability. The aims of the present review...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allergens
Share to Aging
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multifactorial Inheritance

Share to Phenotype

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 37416935
DOI: 10.1111/ahg.12520
PMCID: PMC10952323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pitfalls of predicting age-related traits by polygenic risk scores.PMID 37416935Read ↗

Polygenic Risk Scores in Alzheimer's Disease Genetics: Methodology, Applications, Inclusion, and Diversity.Semantic proximity Read ↗

Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s DiseaseSemantic proximity Read ↗

Polygenic Risk Scores in Neurodegenerative Diseases: a ReviewSemantic proximity Read ↗

Polygenic risk scores: from research tools to clinical instruments.Semantic proximity Read ↗

Polygenic Risk Score Reveals Genetic Heterogeneity of Alzheimer's Disease between the Chinese and European Populations.Semantic proximity Read ↗

Utility of Polygenic Risk Scores in Families with Exceptional LongevitySemantic proximity Read ↗

Age-related late-onset disease heritability patterns and implications for genome-wide association studiesSemantic proximity Read ↗

Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores.Semantic proximity Read ↗

Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structure.Semantic proximity Read ↗

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores is most accurate when using all genetic information.Semantic proximity Read ↗

Genome-wide association studies for Alzheimer’s disease: bigger is not always betterSemantic proximity Read ↗

Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.