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Association of polygenic risk scores with Alzheimer's disease and plasma biomarkers among Chinese older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2024

Hou Tingting, Liu Keke, Fa Wenxin, Liu Cuicui, Zhu Min, Liang Xiaoyan, Ren Yifei, Xu Shan, Wang Xiang, Tang Shi, Wang Yongxiang, Cong Lin, Tan Qihuan, Du Yifeng, Qiu Chengxuan

Abstract excerpt

INTRODUCTION: We examined the associations of polygenic risk score (PRS) with Alzheimer's disease (AD) and plasma biomarkers in the Chinese population. METHODS: This population-based study used baseline data from MIND-China (2018; n = 4873) and follow-up data from dementia-free individuals (2014-2018; n = 2117). We measured AD-related plasma biomarkers in a subsample (n = 1256). Data were analyzed using logistic...

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Alzheimer Disease
Amyloid beta-Peptides
Apolipoproteins E
Biomarkers
East Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Risk Score

Longitudinal Studies

Neurofilament Proteins

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PMID: 39171679
DOI: 10.1002/alz.13924
PMCID: PMC11485307

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APOE

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