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Article

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2009

Calvo Sarah E, Pagliarini David J, Mootha Vamsi K

Abstract excerpt

Upstream ORFs (uORFs) are mRNA elements defined by a start codon in the 5' UTR that is out-of-frame with the main coding sequence. Although uORFs are present in approximately half of human and mouse transcripts, no study has investigated their global impact on protein expression. Here, we report that uORFs correlate with significantly reduced protein expression of the downstream ORF, based on analysis of 11,649...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19372376
DOI: 10.1073/pnas.0810916106
PMCID: PMC2669787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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