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Article

A comprehensive catalog of predicted functional upstream open reading frames in humans.

Nucleic acids research - 20 Apr 2018

McGillivray Patrick, Ault Russell, Pawashe Mayur, Kitchen Robert, Balasubramanian Suganthi, Gerstein Mark

Abstract excerpt

Upstream open reading frames (uORFs) latent in mRNA transcripts are thought to modify translation of coding sequences by altering ribosome activity. Not all uORFs are thought to be active in such a process. To estimate the impact of uORFs on the regulation of translation in humans, we first circumscribed the universe of all possible uORFs based on coding gene sequence motifs and identified 1.3 million unique...

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Identifiers

PMID: 29562350
DOI: 10.1093/nar/gky188
PMCID: PMC6283423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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