Article
Molecular characterization of patient-derived human pancreatic tumor xenograft models for preclinical and translational development of cancer therapeutics.
Neoplasia (New York, N.Y.) - 1 Oct 2013
Mattie Mike, Christensen Ashley, Chang Mi Sook, Yeh William, Said Suzanne, Shostak Yuriy, Capo Linnette, Verlinsky Alla, An Zili, Joseph Ingrid, Zhang Yi, Kumar-Ganesan Sathish, Morrison Karen, Stover David, Challita-Eid Pia
Abstract excerpt
Preclinical evaluation of novel cancer agents requires models that accurately reflect the biology and molecular characteristics of human tumors. Molecular profiles of eight pancreatic ductal adenocarcinoma patient tumors were compared to corresponding passages of xenografts obtained by grafting tumor fragments into immunocompromised mice. Molecular characterization was performed by copy number analysis, gene...
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