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The fidelity of cancer cells in PDX models: Characteristics, mechanism and clinical significance

3 Sept 2019

Abstract excerpt

Patient-derived xenograft (PDX) models are widely used as preclinical cancer models and are considered better than cell culture models in recapitulating the histological features, molecular characteristics and intratumoral heterogeneity (ITH) of human tumors. While the PDX model is commonly accepted for use in drug discovery and other translational studies, a growing body of evidence has suggested its...

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PMID: 31479514
DOI: 10.1002/ijc.32662

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