Article

REWRITE Enables Locus-Scale Engineering of Synthetic HLA Haplotypes in Human Pluripotent Stem Cells

2025-09-16

Abstract excerpt

Human leukocyte antigen (HLA) polymorphism underlies antigen presentation, immune recognition, and central tolerance, yet the complex, multigenic structure of native HLA loci has precluded systematic engineering in human pluripotent stem cells (hPSCs). Existing genome engineering demonstrations in hPSCs focus on smaller integrations or at ectopic sites, leaving scar-minimized rewriting of native human loci at >100...

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Literature Corpus work: e1d52b34-6260-5e7e-bb4d-8d874d933f06
DOI: 10.1101/2025.09.16.676382

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