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Article

Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives.

Scientific reports - 3 Mar 2020

Jo Hye-Yeong, Han Hyo-Won, Jung Inuk, Ju Ji Hyeon, Park Soon-Jung, Moon Sunghwan, Geum Dongho, Kim Hyemin, Park Han-Jin, Kim Sun, Stacey Glyn N, Koo Soo Kyung, Park Mi-Hyun, Kim Jung-Hyun

Abstract excerpt

Although human induced pluripotent stem cell (hiPSC) lines are karyotypically normal, they retain the potential for mutation in the genome. Accordingly, intensive and relevant quality controls for clinical-grade hiPSCs remain imperative. As a conceptual approach, we performed RNA-seq-based broad-range genetic quality tests on GMP-compliant human leucocyte antigen (HLA)-homozygous hiPSCs and their derivatives...

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Identifiers

PMID: 32127560
DOI: 10.1038/s41598-020-60466-9
PMCID: PMC7054319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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