Article

Mouse genomic rewriting and tailoring: synthetic <i>Trp53</i> and humanized <i>ACE2</i>

2022-06-23

Abstract excerpt

Genetically Engineered Mouse Models (GEMMs) aid in understanding human pathologies and developing new therapeutics, yet recapitulating human diseases authentically in mice is challenging to design and execute. Advances in genomics have highlighted the importance of non-coding regulatory genome sequences controlling spatiotemporal gene expression patterns and splicing to human diseases. It is thus apparent that inc...

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Identifiers and source

Literature Corpus work: 6c7aac19-1ef7-50d0-b8a0-1f272e6d3c51
DOI: 10.1101/2022.06.22.495814

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