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Article

Mouse genome rewriting and tailoring of three important disease loci.

Nature - 1 Nov 2023

Zhang Weimin, Golynker Ilona, Brosh Ran, Fajardo Alvaro, Zhu Yinan, Wudzinska Aleksandra M, Ordoñez Raquel, Ribeiro-Dos-Santos André M, Carrau Lucia, Damani-Yokota Payal, Yeung Stephen T, Khairallah Camille, Vela Gartner Antonio, Chalhoub Noor, Huang Emily, Ashe Hannah J, Khanna Kamal M, Maurano Matthew T, Kim Sang Yong, tenOever Benjamin R, Boeke Jef D

Abstract excerpt

Genetically engineered mouse models (GEMMs) help us to understand human pathologies and develop new therapies, yet faithfully recapitulating human diseases in mice is challenging. Advances in genomics have highlighted the importance of non-coding regulatory genome sequences, which control spatiotemporal gene expression patterns and splicing in many human diseases1,2. Including regulatory extensive genomic...

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Identifiers

PMID: 37914927
DOI: 10.1038/s41586-023-06675-4
PMCID: PMC10632133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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