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Concise Review: Human Cell Engineering: Cellular Reprogramming and Genome Editing

8 Sept 2011

Abstract excerpt

Cell engineering is defined here as the collective ability to both reset and edit the genome of a mammalian cell. Until recently, this had been extremely challenging to achieve as nontransformed human cells are significantly refractory to both these processes. The recent success in reprogramming somatic cells into induced pluripotent stem cells that are self-renewable in culture, coupled with our increasing...

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PMID: 21905170
DOI: 10.1002/stem.735

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