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Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

6 Jun 2013

Abstract excerpt

Long-term engraftment of allogeneic cells necessitates eluding immune-mediated rejection, which is currently achieved by matching for human leukocyte antigen (HLA) expression, immunosuppression, and/or delivery of donor-derived cells to sanctuary sites. Genetic engineering provides an alternative approach to avoid clearance of cells that are recognized as "non-self" by the recipient. To this end, we developed...

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PMID: 23741009
DOI: 10.1182/blood-2013-03-478255

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