Article

Discovery and validation of novel human genomic safe harbor sites for gene and cell therapies

2021-03-05

Abstract excerpt

<h4>Summary</h4> Existing approaches for the integration and expression of genes of interest in a desired human cellular context are marred by the safety concerns related to either the random nature of viral-mediated integration or unpredictable pattern of gene expression in currently employed targeted genomic integration sites. Disadvantages of these methods lead to their limited use in clinical practice, thus e...

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Literature Corpus work: 01c311d0-cfac-52df-88a4-4f3277f10b82
DOI: 10.1101/2021.03.04.433856

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