Article

Immune and Mutational Profile of Gene-Edited Low-Immunogenic Human Primary Cholangiocyte Organoids

2025-01-22

Abstract excerpt

<h4>ABSTRACT</h4> Primary human cells cultured in organoid format have great promise as potential regenerative cellular therapies. However, their immunogenicity and mutational profile remain unresolved, impeding effective long-term translation to the clinic. In this study we report, for the first time, the generation of human leukocyte antigen (HLA)-I and HLA-II knock-out expandable human primary cholangiocyte or...

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Literature Corpus work: 9015741f-d5e9-5b5a-9d08-500a3eade15c
DOI: 10.1101/2025.01.20.628680

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