Article

Deletion of Robo4 worsens neuroinflammation and motor coordination in a mouse model of Alzheimer’s disease

2024-03-12

Abstract excerpt

Declines in vascular integrity are potential contributors to Alzheimer’s disease (AD) as these result in increased blood-brain barrier permeability and, as a consequence, accelerate neuroinflammation and cognitive impairment. Roundabout guidance receptor 4 (Robo4) is primarily expressed in endothelial cells and stabilizes the vasculature, and thus, has the potential to protect the brain in AD. To study the effect...

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Literature Corpus work: e1ca3e2e-f18a-55e2-a369-a06d58230953
DOI: 10.1101/2024.03.07.583582

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