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Article

Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes

27 Jun 2019

Abstract excerpt

Sufficient vascular supply is indispensable for brain development and function, whereas dysfunctional blood vessels are associated with human diseases such as vascular malformations, stroke or neurodegeneration. Pericytes are capillary-associated mesenchymal cells that limit vascular permeability and protect the brain by preserving blood-brain barrier integrity. Loss of pericytes has been linked to...

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PMID: 31249304
DOI: 10.1038/s41467-019-10643-w

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