Article

Pericyte ablation causes hypoactivity and reactive gliosis in adult mice

2023-10-31

Abstract excerpt

Pericytes are contractile cells that enwrap capillaries allowing them to control blood flow, maintain the blood-brain barrier and regulate immune cell trafficking in the CNS. Pericytes are lost or become dysfunctional in neurodegenerative diseases such as Alzheimer’s disease, stroke, and multiple sclerosis, but their role in health and disease is poorly understood. Our aim was to evaluate blood-brain barrier integ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ce149ee-e4f0-546e-8c23-f1063da40fa2
DOI: 10.1101/2023.10.26.564269

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pericyte ablation causes hypoactivity and reactive gliosis in adult miceDOI 10.1101/2023.10.26.564269Read

Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytesSemantic proximity Read

Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging.Semantic proximity Read

Mild pericyte deficiency is associated with aberrant brain microvascular flow in aged PDGFRβ+/- mice.Semantic proximity Read

Pericytes regulate vascular immune homeostasis in the CNSSemantic proximity Read

Deletion of Robo4 worsens neuroinflammation and motor coordination in a mouse model of Alzheimer’s diseaseSemantic proximity Read

Disruption of Bmal1 Impairs Blood–Brain Barrier Integrity via Pericyte DysfunctionSemantic proximity Read

The role of pericytic laminin in blood brain barrier integrity maintenance.Semantic proximity Read

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesionsSemantic proximity Read

Multiregional blood-brain barrier phenotyping identifies the prefrontal cortex as the most vulnerable region to ageing in miceSemantic proximity Read

Cardiac pericytes are necessary for coronary vasculature integrity and cardiomyocyte differentiationSemantic proximity Read

<i>Atp13a5</i> Marker Reveals Pericytes of The Central Nervous System in MiceSemantic proximity Read

DYRK1A haploinsufficiency affects the development of astroglia and oligodendroglia, and axonal conductivity in the brainSemantic proximity Read