Article

Multiregional blood-brain barrier phenotyping identifies the prefrontal cortex as the most vulnerable region to ageing in mice

2025-03-10

Abstract excerpt

Age-associated vascular alterations make the brain more vulnerable to neuropathologies. Research in humans and rodents have demonstrated structural, molecular, and functional alterations of the aged brain vasculature that suggest blood-brain barrier (BBB) dysfunction. However, these studies focused on particular features of the BBB and specific brain regions. Thus, it remains unclear if and which BBB age-associate...

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Literature Corpus work: 670bc736-0aa2-506c-b261-28bb462e062d
DOI: 10.1101/2025.03.09.642233

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