Article

Inhibition of β-catenin signaling by Amyloid-β in endothelial cells impairs vascular barrier integrity

2024-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Dysfunction of the blood-brain barrier (BBB) is emerging as a critical mediator of Alzheimer’s Disease (AD) progression and precedes the formation of large Amyloid-β (Aβ) plaques in AD patients. Maintenance of the blood brain barrier integrity by brain microvascular endothelial cells (BMECs) is essential for brain homeostasis and is in part maintained by WNT/β-catenin signaling. We hypothesized...

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Literature Corpus work: 5def39cd-3797-5841-9341-82cb1f08d03f
DOI: 10.1101/2024.11.05.622172

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