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Article

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction.

PLoS biology - 1 Oct 2015

Soto Ileana, Graham Leah C, Richter Hannah J, Simeone Stephen N, Radell Jake E, Grabowska Weronika, Funkhouser W Keith, Howell Megan C, Howell Gareth R

Abstract excerpt

Aging is the major risk factor for neurodegenerative diseases such as Alzheimer's disease, but little is known about the processes that lead to age-related decline of brain structures and function. Here we use RNA-seq in combination with high resolution histological analyses to show that aging leads to a significant deterioration of neurovascular structures including basement membrane reduction, pericyte loss,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26512759
DOI: 10.1371/journal.pbio.1002279
PMCID: PMC4626092

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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