Article

A single dose of the antipsychotic drug clozapine has long-term behavioral and functional effects in mice

2026-03-31

Abstract excerpt

<h4>SUMMARY</h4> Antipsychotic dosing regimens, commonly daily or via slow-release compounds, are designed to maintain steady-state plasma concentrations. They are guided by their plasma half-life that is typically in the range of several hours. This schedule contrasts with the slow time course of therapeutic efficacy, which often takes weeks to develop fully. This discrepancy led us to hypothesize that the effec...

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Literature Corpus work: e1c1004e-5b96-50e1-8adf-6b88d1f2cb39
DOI: 10.64898/2026.03.27.714783

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