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Article

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia.

Nature medicine - 1 Mar 2017

Koukouli Fani, Rooy Marie, Tziotis Dimitrios, Sailor Kurt A, O'Neill Heidi C, Levenga Josien, Witte Mirko, Nilges Michael, Changeux Jean-Pierre, Hoeffer Charles A, Stitzel Jerry A, Gutkin Boris S, DiGregorio David A, Maskos Uwe

Abstract excerpt

The prefrontal cortex (PFC) underlies higher cognitive processes that are modulated by nicotinic acetylcholine receptor (nAChR) activation by cholinergic inputs. PFC spontaneous default activity is altered in neuropsychiatric disorders, including schizophrenia-a disorder that can be accompanied by heavy smoking. Recently, genome-wide association studies (GWAS) identified single-nucleotide polymorphisms (SNPs) in...

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Identifiers

PMID: 28112735
DOI: 10.1038/nm.4274
PMCID: PMC5819879

Genes

CHRNA5
VIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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