Article

Synaptic editing of frontostriatal circuitry prevents excessive grooming in SAPAP3-deficient mice

2025-03-29

Abstract excerpt

<h4>Summary</h4> Synaptic dysfunction has been implicated as a key mechanism underlying the pathophysiology of psychiatric disorders. Most pharmacological therapeutics for schizophrenia, autism spectrum disorder, obsessive-compulsive disorder, and major depressive disorder temporarily augment chemical synapse function. Nevertheless, medication non-compliance is a major clinical challenge, and behavioral dysfuncti...

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Literature Corpus work: b234966f-5627-5302-8244-89167b4b22e2
DOI: 10.1101/2025.03.27.645613

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