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Article

Resolving and Rescuing Developmental Miswiring in a Mouse Model of Cognitive Impairment.

Neuron - 8 Jan 2020

Chini Mattia, Pöpplau Jastyn A, Lindemann Christoph, Carol-Perdiguer Laura, Hnida Marilena, Oberländer Victoria, Xu Xiaxia, Ahlbeck Joachim, Bitzenhofer Sebastian H, Mulert Christoph, Hanganu-Opatz Ileana L

Abstract excerpt

Cognitive deficits, core features of mental illness, largely result from dysfunction of prefrontal networks. This dysfunction emerges during early development, before a detectable behavioral readout, yet the cellular elements controlling the abnormal maturation are still unknown. Here, we address this open question by combining in vivo electrophysiology, optogenetics, neuroanatomy, and behavioral assays during...

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Identifiers

PMID: 31733940
DOI: 10.1016/j.neuron.2019.09.042
PMCID: PMC6953432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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