Article

Carbamazepine restores neuronal signaling, protein synthesis and cognitive function in a mouse model of fragile X syndrome

2020-01-08

Abstract excerpt

<h4>ABSTRACT</h4> Fragile X syndrome (FXS) is a leading genetic disorder of intellectual disability caused by the loss of the functional fragile X mental retardation protein (FMRP). To date, there is no efficacious mechanism-based medication for FXS. With regard to potential disease mechanisms in FXS, it is widely accepted that the lack of FMRP causes elevated protein synthesis and deregulation of neuronal signal...

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Literature Corpus work: 2d2452cd-e50d-5d9c-9271-d01bb8a30ef2
DOI: 10.1101/2020.01.07.897835

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