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Reactivating a schizophrenia risk gene-enriched prefrontal ensemble suppresses decision noise

2026-06-17

Abstract excerpt

Schizophrenia genetics and single-cell transcriptomics implicate prefrontal excitatory neurons and synaptic programs, but how these vulnerabilities alter circuit dynamics, behavior, and pharmacological targetability remains unclear. We identify a clozapine-responsive prefrontal ensemble enriched for schizophrenia risk genes that stabilizes value-guided choice. NMDA receptor hypofunction increased value-independent...

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Literature Corpus work
680e4af6-67a9-5294-84a6-294908da6fab
DOI
10.64898/2026.06.14.732113
Open publication

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Reactivating a schizophrenia risk gene-enriched prefrontal ensemble suppresses decision noiseDOI 10.64898/2026.06.14.732113
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