Article

Sleep deprivation rapidly upregulates serotonin 2A receptor expression via the immediate early gene <i>Egr3</i>

2019-05-10

Abstract excerpt

Serotonin 2A receptors (5-HT 2A Rs) mediate the effects of hallucinogenic drugs and antipsychotic medications, and are reduced in schizophrenia patients’ brains. However, the mechanisms that regulate 5-HT 2A R expression remain poorly understood. We show that an environmental stimulus, sleep deprivation, upregulates 5-HT 2A Rs in the mouse frontal cortex (FC) in just 6-8 hours. This induction requires the immed...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb84d5f6-8736-5270-a14e-c0f6be5ce621
DOI: 10.1101/634410

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sleep deprivation rapidly upregulates serotonin 2A receptor expression via the immediate early gene <i>Egr3</i>DOI 10.1101/634410Read

Sleep Homeostatic and Waking Behavioral Phenotypes in Egr3-Deficient Mice Associated with Serotonin Receptor 5-HT2 Deficits.Semantic proximity Read

Opioid withdrawal engages a habenular subpopulation responsive to aversive statesSemantic proximity Read

Identification of activity-induced <i>Egr3</i> -dependent genes reveals genes associated with DNA damage response and schizophreniaSemantic proximity Read

A suite of engineered mice for interrogating psychedelic drug actionsSemantic proximity Read

Spatiotemporal remodeling in the habenula marks the onset of depressionSemantic proximity Read

Reactivation of early-life stress-sensitive neuronal ensembles contributes to lifelong stress hypersensitivitySemantic proximity Read

Glutamatergic neurons in the preoptic hypothalamus promote wakefulness, destabilize NREM sleep, suppress REM sleep, and regulate cortical dynamicsSemantic proximity Read

Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of the <i>Apoe</i> geneSemantic proximity Read

A single dose of the antipsychotic drug clozapine has long-term behavioral and functional effects in miceSemantic proximity Read

The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in miceSemantic proximity Read

Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenulaSemantic proximity Read

Nuclear Receptor 5A2 Regulation of <i>Agrp</i> underlies Olanzapine-induced HyperphagiaSemantic proximity Read