Article

Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

2021-07-23

Abstract excerpt

The rate of nonalcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing worldwide, but the steps in precancerous hepatocytes which lead to HCC driver mutations are not well understood. Here we provide evidence that metabolically-driven histone hyperacetylation in steatotic hepatocytes can increase DNA damage to initiate carcinogenesis. Genome-wide histone acetylation is increas...

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Identifiers and source

Literature Corpus work: 775db9cc-9764-5109-a8a9-f29d6a4819b7
DOI: 10.1101/2021.07.22.453333

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